DO NOT PLACE IN THE MEDICAL RECORD
Developed by the Acute Liver Failure Study Group
Published in PLoS ONE
A checklist for experienced providers to help manage patients with acute liver failure in the ICU
Completed:
Drug / toxin | Obtain 6-month medication/toxin/ingestion history including OTC supplements, herbals, wild mushrooms, weight loss drugs Urine and serum toxicology screens Acetaminophen level |
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Viral | Anti-HAV IgM HBsAg, anti-HBc IgM, HBV DNA (quantitative) Anti-HCV, HCV RNA |
Autoimmune | Antinuclear antibody Anti-smooth muscle antibody/anti-actin antibody Immunoglobulin G |
Vascular / Budd-Chiari / Ischemia | Abdominal ultrasound with Doppler |
Wilson | Check for hemolytic anemia (high indirect bilirubin), low alkaline phosphatase, renal failure, acidosis |
Viral | Anti-HEV HSV DNA EBV DNA CMV DNA Anti-HDV/HDV RNA |
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Autoimmune | Anti-liver/kidney microsomal antibody Liver biopsy |
Vascular / Budd Chiari / Ischemia | CT/MRI Assess for hypercoagulable state including search for malignancy Interventional radiology consultation Echocardiography/ECG |
Wilson | Ceruloplasmin 24-hour urine for copper Serum copper Ophthalmology consultation to look for Kayser-Fleischer rings |
Acute Fatty Liver of Pregnancy / HELLP | β-HCG Obstetrics consultation |
Malignancy | CT/MRI Liver biopsy |
Indeterminate | Liver biopsy |
Acetaminophen toxicity | N-acetylcysteine (NAC) |
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Mushroom poisoning | Charcoal, NAC, penicillin G and/or silibinin |
HBV | Entecavir |
HSV | Acyclovir |
Autoimmune | Corticosteroids |
Budd Chiari | Anticoagulation, TIPS |
Wilson | Consider early CRRT |
Acute Fatty Liver of Pregnancy / HELLP | Early delivery |